Upadhyaya Lab

laboratory for cellular biophysics :: department of physics :: university of maryland


  1. M. Azatov, X. Sun, A. Suberi, J.T. Fourkas and A. Upadhyaya*, “Topography on a subcellular scale modulates cellular adhesions and actin stress fiber dynamics in tumor associated fibroblasts”, Phys. Biol., doi: 10.1088/1478-3975/aa7acc (2017).
  2. K.L. Hui and A. Upadhyaya*, “Dynamic microtubules regulate cellular contractility during T-cell activation”, Proc. Natl. Acad. Sci., 114:E4175 (2017).
  3. M. Azatov, S.M. Goicoechea, C.A. Otey and A. Upadhyaya*, “The actin crosslinking protein palladin modulates force generation and mechanosensitivity of tumor associated fibroblasts”, Sci. Rep., 29:28805 (2016).
  4. K.L. Hui†, L. Balagopalan, L.E. Samelson, and A. Upadhyaya*, “Cytoskeletal forces during signaling activation in Jurkat T cells”, Mol. Biol. Cell, 26:685 (2015).
  5. C. Ketchum†, C. Liu, H. Miller, W. Song and A. Upadhyaya*, “Ligand mobility regulates B cell receptor clustering and signaling activation”, Biophys. J., 106:26-36 (2014).
  6. M. Seeley-Fallen, L.J. Liu, M. Shapiro, O. Onabajo, S. Palaniyandi, X. Zhu, T.H. Tan, A. Upadhyaya and W. Song*, "Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways.", Proc. Natl. Acad. Sci., 111:9881-9886 (2014).
  7. K. L. Hui†, S. Kwak‡ and A. Upadhyaya*, “Adhesion dependent modulation of actin dynamics in Jurkat T cells”, Cytoskeleton, 71:119-135 (2014).
  8. W. Song*, C. Liu and A. Upadhyaya*, “The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation”, Biophysica Biochimica Acta Biomembranes, 1838:569 (2014).
  9. W. Song*, C. Liu, M. K. Seeley-Fallen, H. Miller, C. Ketchum and A. Upadhyaya*, “Actin-mediated feedback loops in B cell receptor signaling”, Immunological Reviews, 256:177-189 (2013).
  10. C. Liu, X. Bai, J. Wu, S. Sharma, A. Upadhyaya, C. Dahlberg, L. S. Westerberg, S. B. Snapper, X. Zhao, and W. Song*, “N-WASP is essential for the negative regulation of B cell antigen receptor signaling”, PLoS Biol., 11:e1001704 (2013).
  11. C. Liu, M. K. Fallen, H. Miller, A. Upadhyaya, and W. Song*, “The actin cytoskeleton coordinates the signal transduction and antigen processing functions of the B cell antigen receptor”, Frontiers in Biology, 8:475-485 (2013).
  12. C. Liu, H. Miller, S. Sharma, A. Beavan, K. Richard, A. Upadhyaya*, and W. Song*, “Analyzing actin dynamics during the activation of the B cell receptor in live B cells”, Biochem. Biophys. Res. Commun. 427: 202 (2012).
  13. B. Grooman†, I. Fujiwara, C. A. Otey and A. Upadhyaya*, “Morphology and viscoelasticity of actin networks crosslinked with the mutually interacting crosslinkers: palladin and alpha-actinin”, PLoS One, 7:e42773 (2012).
  14. C. Liu, H. Miller, G. Orlowsky, H. Hong, A. Upadhyaya, and W. Song*, “Actin reorganization is required for the formation of polarized B cell receptor signalosomes in response to both soluble and membrane-associated antigens”, J. Immunology, 188: 3237, (2012).
  15. K. L. Hui†, J. Wayt‡, B. Grooman and A. Upadhyaya*, “Membrane dynamics correlate with formation of signaling clusters during cell spreading”, Biophys. J., 102: 1524 (2012).
  16. C. Liu, H. Miller, G. Orlowsky, , S. Sharma, K. L. Hui, B. Grooman, A. Upadhyaya*, and W. Song*, “A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling”, J. Immunology, 187: 230 (2011).
  17. A. Upadhyaya*, J. Wong, M. Daniels, A. van Oudenaarden and L. Mahadevan* Power-limited contraction dynamics of Vorticella convallaria: an ultra-fast biological spring, Biophys. J. 94: 265 (2008).
  18. W. G. Tharp, R. Yadav, D. Irimia, A. Upadhyaya et al. Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo, J. Leukocyt. Biol. 79: 539-554 (2006).
  19. A. Upadhyaya* and A. van Oudenaarden*, Actin polymerization: forcing flat faces forward, Curr. Biol. 14: R467 (2004).
  20. B. T. Nguyen, A. Upadhyaya, A. van Oudenaarden and M.P. Brenner* Elastic instability in a growing yeast droplet, Biophys. J., 86, 2720 (2004).
  21. A. Upadhyaya* and M. P. Sheetz*, Measurement of membrane tension in tubulovesicular networks of ER and Golgi using optical tweezers, Biophys. J. 86, 2923 (2004).
  22. N. B. Ouchi, J. A. Glazier, J. P. Rieu, A. Upadhyaya, and Y. Sawada, Improving the realism of the cellular Potts model in simulations of biological cells, Physica A, 329, 451 (2003).
  23. A. Upadhyaya* and A. van Oudenaarden*, Biomimetic systems for studying actin-based motility, Curr. Biol. 13, R734 (2003).
  24. A. Upadhyaya*, J. C. Chabot, A. Andreeva A. Samadani and A. van Oudenaarden*, Probing polymerization forces using actin propelled lipid vesicles, Proc. Nat. Acad. Sci. 100, 4521 (2003).
  25. M. J. Powers, K. Domansky, M. R. Kaazempur-Mofrad, A. Kalezi, A. Capitano, A. Upadhyaya, P. Kurzawski, K. E. Wack, D. B. Stolz, R. Kamm, and L. G. Griffith, A microfabricated array bioreactor for perfused 3D liver culture, Biotechnol. Bioeng. 78, 257 (2002).
  26. J. C. M. Mombach, R. M. C. de Almeida, G. L. Thomas, A. Upadhyaya, and J. A. Glazier*, Bursts and cavity formation in Hydra cell aggregates: Experiments and simulations, Physica A, 297, 495 (2001).
  27. A. Upadhyaya, J. P. Rieu, Y. Sawada*, J. A. Glazier*, Anomalous diffusion and non-Gaussian velocity distribution of Hydra cells in cellular aggregates, Physica A, 293, 549 (2001). Elemental discoveries
  28. J. P. Rieu, A. Upadhyaya, Y. Sawada, N.B. Ouchi and J. A. Glazier*, Diffusion and deformations of single Hydra cells in cellular aggregates, Biophys. J., 79, 1903 (2000).
  29. "First steps towards acomprehensive model of tissues" J. A. Glazier and A. Upadhyaya, Dynamical Networks in Physics and Biology, (D. Beysens and G. Forgacs eds. Springer Berlin, 1998).