Upadhyaya Lab

laboratory for cellular biophysics :: department of physics :: university of maryland

Our laboratory aims to understand how cellular mechanics and physical forces enable a cell to sense and respond to its physical environment. We are particularly interested in the regulation of the biochemical signaling function in cells during the immune response, cancer and development. We combine quantitative imaging, computational analysis and approaches from soft condensed matter with genetic manipulation and modern cell biology to uncover how cellular forces are linked with signal transduction.

read our latest paper

Cytoskeletal forces during signaling activation in Jurkat T cells

Hui, K.L., Balagopalan, L., Samelson, L.E. and Upadhyaya, A. Mol. Biol. Cell (2015)